发布时间:2021-10-09 来源:
朱友明,男,2013年获中国科学技术大学生命科学学院理学博士学位,副教授,硕士生导师。主要从事干细胞分化,癌症发生分子机理研究,同时与团队成员共同致力于口腔癌发病分子机理以及利用干细胞进行骨形成和血管形成的研究,在安医大工作期间,主要从事本科生口腔生物学教学,指导研究生开展科研工作和中心实验室日常管理工作,主持国家自然科学基金2项,省自然科学基金1项,安医大博士基金一项,安徽医科大学科研水平提升计划一项,口腔医学院卓越人才计划。相关研究成果发表于MolecularCell,Cell reports,Cell Death and Differentiation,cell reports,Oncogene,Stem Cells,ActaBiomaterialia等国际知名杂志。
主持的科研课题:
1.主持国家自然科学基金面上项目:lncRNA-vtrb介导的血管化组织工程骨对颅颌面临界骨缺损的修复作用和机制研究(31970677),202001-202312,在研;
2.主持安徽省优秀青年科学基金项目:他汀类药物通过c-Myc—LncRNA CROPR信号轴影响OSCC进展的研究(2308085Y23),202309-202609,在研
3.主持安徽医科大学口腔医学院卓越人才计划,在研
4.主持安徽医科大学科研水平提升计划:lncRNA-vtrb和NUP62介导的血管化组织工程骨对CSD的修复作用和机制研究(2019xkjT010),202001-202212,已结题;
5.主持国家自然科学基金青年基金:IGF2BP1在细胞分化中作用机制的研究(31501103),2016/01-2018/12,已结题;
6.主持安徽省自然科学基金:cdpf1在细胞分化中作用机制的研究(1508085QC62),2015/07-2017/06,已结题;
7.主持安徽科学大学博士科研基金:cdpf1在细胞分化中作用机制的研究(0401062101),2014/07-2016/06,已结题。
期刊论文:
1. Youming Zhu#, Lei Jin#,Ronghua Shi, Jinming Li,Yan Wang,LiZhang, Chao-Zhao Liang, Vinod K. Narayana, David P. De Souza, Rick F. Thorne,Li Rong Zhang*, Xu Dong Zhang*, Mian Wu*.Long noncoding RNA glycoLINC assemblesa lower glycolytic complex to promote glycolysis.Molecular Cell. 2022 Feb3;82(3):542-554.
2. Zhu Youming#; Peng Wang#; LiZhang; Guo Bai; Chi Yang ; Yuanying Wang; Youming Zhu, Jiacai He; ZhiyuanZhang; Guoping Zhu; Duohong Zou.Superhero Rictor promotes cellulardifferentiation of mouse embryonic stem cells .Cell Death and Differentiation,2018.8.28 10(1038).
3. Qidong Li,HanhuiYao,Yichun Wang, Yang Wu, Rick F. Thorne,Youming Zhu,* Mian Wu* ,LianxinLiu*.circPRKAA1 activates a Ku80/Ku70/SREBP-1 axis driving de novo fatty acidsynthesis in cancer cells.Cell Reports ,202211. 22, 41, 111707. (共同通讯)
4. Fengyang Jing , JianxiongWang , Liming Zhou , Yujie Ning , Shengqian Xu , Youming Zhu* ;Bioinformaticsanalysis of the role of CXC ligands in the microenvironment of head and necktumor;Aging (Albany NY),2021Jul 11;13(13):17789-17817
5. Xiaofeng Qin, Yujie Ning, Liming Zhou, Youming Zhu*.OralSubmucous Fibrosis: Etiological Mechanism, Malignant Transformation,Therapeutic Approaches and Targets.Int J Mol Sci. 2023 Mar 5;24(5):4992.
6. Linfei Feng, Fengyang Jing, Xiaofeng Qin, Liming Zhou, Yujie Ning, Jun Hou, WeihaoKong, Youming Zhu*.Cleavage Stimulation FactorSubunit 2:Function Across Cancers and Potential Target for ChemotherapeuticDrugs.Frontiers in Pharmacology.2022 Mar 18;13:852469.
7. Feng-Yang Jing , Li-Ming Zhou , Yu-Jie Ning , Xiao-Juan Wang , You-Ming Zhu* ;Thebiological function, mechanism, and clinical significance of m6A RNAmodifications in head and neck carcinoma: A systematic review;FrontCell Dev Biol,2021 May 31;9:683254
8. Zhu Y#; Yao Z ; Wu Z; Mei Y ;Wu M.Role of tumor necrosis factor alpha-induced protein 1 in paclitaxelresistance ,Oncogene 2014.8.5 33(25):3246~3255
9. Zhou Yong#;ZhuYouming#; Zhang Li ; Wu Tao; Wu Tingting; Zhang Wenjie; Decker Ann Marie;He Jiacai; Liu Jie; Wu Yiqun; Jiang Xinqun; Zhang Zhiyuan; Liang Chaozhao; ZouDuohong.Human Stem Cells Overexpressing miR-21 Promote Angiogenesis in CriticalLimb Ischemia by Targeting CHIP to Enhance HIF-1 Activity ,Stem Cells 2016.0434(4) :924~934 . (共同第一)
10. Hu Bin; Li Yan;WangMohan;Zhu Youming#; Zhou Yong; Sui Baiyan; Tan Yu; Ning Yujie; Wang Jie;He Jiacai; Yang Chi; Zou Duohong . Functional reconstruction of critical-sizedload-bearing bone defects using a Sclerostin-targeting miR-210-3p-basedconstruct to enhance osteogenic activit, Acta Biomaterialia 2018.08 76 :275~282 (共同第一)
11. Bian M; Li S; Wei H;Huang S;Zhou F;Zhu Youming*;Zhu G. Heteroexpression and biochemicalcharacterization of a glucose-6-phosphate dehydrogenase from oleaginous yeastYarrowia lipolytica. Protein Expression and Purification,2018Aug;148:1-8. (共同通讯)
12. Lv Changqi ; Wang Peng;Wang Wencai; Su Ruirui; Ge Yadong;Zhu Youming*; Zhu Guoping.Twoisocitrate dehydrogenases from a plant pathogen Xanthomonas campestris pv.campestris 8004. Bioinformatic analysis, enzymatic , characterization, andimplication in virulence, Journal of Basic Microbiology,2016.09,56(9): 975-985.(共同通讯)
获奖情况:
高等学校科学研究优秀成果奖(科学技术)科学技术进步奖二等奖(排名第8)
2018安徽医科大学最具影响力论文
2021-2022年度安徽医科大学优秀教师
2018口腔医学院优秀科技工作者
2019口腔医学院优秀科技工作者
2021口腔医学院优秀科技工作者
2020-2021口腔医学院优秀基础教师