发布时间:2021-08-26 来源:
个人信息:
李全利,男,1966年出生,科学学位博士研究生导师,科学学位与专业学位硕士研究生导师;
口腔医学博士,安徽医科大学口腔医学院教授;
中华口腔医学会口腔材料专业委员会委员;
安徽省口腔医学会口腔修复学专委会副主任委员,候任主任委员;
先后于四川大学华西口腔医学院获学士(1991年)、硕士(1997年)、博士学位(2005年);
曾在西南交通大学从事博士后研究(2006-2008年),香港大学牙医学院研修(2012年,2014年);
科研方向:
基础科学研究:人体硬组织修复材料的设计、合成、表面改性、生物医学效应与机理;目前主要从事采取非细胞策略的仿生矿化技术诱导牙体组织结构的再生与构建的研究,以及改善牙本质粘接持久性的研究。
临床研究:目前主要从事口腔修复体的仿生设计、牙体缺损的微创修复、咬合重建技术体系、种植修复技术的研究,以及相关学科问题的循证医学研究。
科研课题:
1、国家自然科学基金国际(地区)合作项目(中国香港)(NSFC-RGC):龋病预防新策略“特异性抗菌--矿化平衡调控”功能的牙齿亲和性抗菌肽的构建(No: 82061160492),2021.01-2024.12,98万元,在研、主持;
2. 国家自然科学基金面上项目:项目编号:81970983,等级结构类釉质宏观块材的组装、2020/01-2024/12、55.00 万,主持, 在研。
3. 国家自然科学基金面上项目: 项目编号:81571018, “去污和矿化”双活性表面诱导釉质样结构再生的愈性修复2016.01-2019,12,- RMB:67.8万元, 结题
4.国家自然科学基金国际(地区)合作项目(中国香港)(NSFC-RGC):项目编号:81061160511,分子仿生诱导釉质微结构宏观再生的研究,2011-2013,- RMB $ 310,000, 结题
5.国家自然科学基金面上项目:项目编号:30973352, 釉质仿生材料的模型构建,2010-2012,- RMB $ 290,000, 结题
6. 安徽省科技攻关项目:项目编号:1804h08020232.直流电场辅助的分子仿生诱导牙齿微结构再生的临床转化研究、 2019/01-2021/12, 30万,主持 在研
7. 合肥市自主创新政策“借转补”项目:项目编号:YW201710120001, 仿生矿化诱导牙体组织自愈性再生修复牙科新型制剂的临床转化,2017/09-2019/08, 100万,在研
发表论文:
1. Li Zhou; Hai Ming Wong*; Yu Yuan Zhang; Quan Li Li*; Constructing an Antibiofouling and Mineralizing Bioactive Tooth Surface to Protect against Decay and Promote Self-Healing., ACS Applied Materials & Interfaces, 2020, 12(2): 3021-3031
2. Shengrui Wang, Le Zhang, Wendy Chen, Huimin Jin, Ya Zhang, Leping Wu, Hui Shao, Zehui Fang, Xiaoxue He, Shunli Zheng, Chris Ying Cao, Hai Ming Wong, QuanliLi*. Rapid regeneration of enamel-like-oriented inorganic crystals by using rotary evaporation. Materials Science and Engineering: C, Volume 115, October 2020, 111141. ttps://doi.org/10.1016/j.msec.2020.111141
3. Qing-qing Wang, Leiying Miao, He Zhang, Si Qing Wang, Quanli Li and Weibin Sun. A novel amphiphilic oligopeptide induced the intrafibrillar mineralisation via interacting with collagen and minerals. J. Mater. Chem. B, 2020,8, 2350-2362
4. Leping Wu; Hui Shao; Zehui Fang; Yuancong Zhao; Chris Ying Cao; Quanli Li*; Mechanism and Effects of Polyphenol Derivatives for Modifying Collagen., ACS Biomater. Sci. Eng., 2019, 5(9): 4272-4284.
5. Zhang Yu Yuan; Wong Hai Ming*; McGrath Colman P J; Li Quan Li*; Repair of dentine-related lesions without a drill or injection., RSC Advances, 2019, 9(26): 15099-15107
6. Zhang L, Li QL*, Cao Y, Wang Y*. Regenerating a monoblock to obturate root canalsvia a mineralising strategy. Sci Rep. 2018 Sep 6;8(1):13356. doi: 10.1038/s41598-018-31643-8.
7. Zhang YY, Wong HM*, McGrath CPJ, Li QL*.In vitro and in vivo evaluation of electrophoresis-aided casein phosphopeptide-amorphous calcium phosphate remineralisation system on pH-cycling and acid-etching demineralised enamel. Sci Rep. 2018 Jun 11;8(1):8904. doi: 10.1038/s41598-018-27304-5.
8. Wang QQ, Dai R, Cao CY, Fang H, Han M, Li QL*.One-time versus repeated abutment connection for platform-switched implant: A systematic review and meta-analysis. PLoS One. 2017 Oct 19;12(10):e0186385.
9. Fang H, Li QL*, Han M, Mei ML, Chu CH*. Anti-proteolytic property and bonding durability of mussel adhesive protein-modified dentin adhesive interface. Dent Mater. 2017 Oct;33(10):1075-1083..
10. Han M, Li QL*, Cao Y, Fang H, Xia R, Zhang ZH. In vivo remineralization of dentin using an agarose hydrogel biomimetic mineralization system. Sci Rep. 2017 Feb 7;7:41955.
11. Li QL*, Ying Cao C, Xu QJ, Xu XH, Yin JL. Atraumatic Restoration of Vertical Food Impaction with an Open Contact Using Flowable Composite Resin Aided by Cerclage Wire under Tension. Scientifica (Cairo). 2016;2016:4127472.
12. Yin J, Mei ML, Li Q*, Xia R, Zhang Z, Chu CH*. Self-cleaning and antibiofouling enamel surface by slippery liquid-infused technique. Sci Rep. 2016 May 16;6:25924.
13. Wu XT, Mei ML, Li QL*, Cao CY, Chen JL, Xia R, Zhang ZH, Chu CH*. A Direct Electric Field-Aided Biomimetic Mineralization System for Inducing the Remineralization of Dentin Collagen Matrix. Materials (Basel). 2015 Nov 20;8(11):7889-7899.
14. Cao CY, Mei ML, Li QL*, Lo EC, Chu CH*. Methods for biomimetic remineralization of human dentine: a systematic review.Int J Mol Sci. 2015 Mar 2;16(3):4615-27.
15. Cao CY, Mei ML ; Li QL* ; Lo ECM ; Chu CH*. Methods for Biomimetic Mineralisation of Human Enamel: A Systematic Review. MATERIALS,2015, 8(6): 2873-2886.
16. Zhang, YY; Mao, WJ; Wang, J Li, QL* ; Mei, ML ; Chu, CH* ; Xia, R; Zhang, ZH. Antibacterial Membrane with a Bone-Like Structure for Guided Bone Regeneration. J NANOMATERIALS, 2015, 784574 784574
17. Cao Y, Mei ML, Li QL*, Lo EC, Chu CH. Enamel prism-like tissue regeneration using enamel matrix derivative. J Dent. 2014 Dec;42(12):1535-42.
18. Li QL*, Ning TY, Cao Y, Zhang WB, Mei ML, Chu CH*. A novel self-assembled oligopeptide amphiphile for biomimetic mineralization of enamel. BMC Biotechnol. 2014 Apr 27;14:32.
19. Wu, XTng; Cao, Y; Mei, ML; Chen, JL; Li, QL* ; Chu, CH*. An Electrophoresis-Aided Biomineralization System for Regenerating Dentin- and Enamel-Like Microstructures for the Self-Healing of Tooth Defects. CRYSTAL GROWTH & DESIGN, 2014, 14(11): 5537-5548
20. Cao Y, Mei ML, Li QL*, Lo EC, Chu CH*. Agarose hydrogel biomimetic mineralization model for the regeneration of enamel prismlike tissue. ACS Appl Mater Interfaces. 2014 Jan 8;6(1):410-20
21. Cao Y, Liu W, Ning T, Mei ML, Li QL*, Lo EC, Chu CH*. A novel oligopeptide simulating dentine matrix protein 1 for biomimetic mineralization of dentine.Clin Oral Investig. 2014 Apr;18(3):873-81.
22. Cao Y, Mei ML, Xu J, Lo EC, Li Q*, Chu CH*. Biomimetic mineralisation of phosphorylated dentine by CPP-ACP. J Dent. 2013 Sep;41(9):818-25
23. Zhou YZ, Cao Y, Liu W, Chu CH, Li QL*. Polydopamine-induced tooth remineralization. ACS Appl Mater Interfaces. 2012 Dec;4(12):6901-10.